Abu Dhabi: Researchers at NYU Abu Dhabi (NYUAD) have developed an ingestible device that could use light to activate neurons in the gut, providing a new non-invasive way to study and potentially treat digestive and metabolic disorders.
The technology, called ICOPS (Ingestible Controlled Optogenetic Stimulation), was created by Khalil Ramadi, Assistant Professor of Bioengineering at NYU Abu Dhabi and NYU Tandon, and his team. ICOPS delivers targeted light inside the gut to stimulate nerve cells. This method is based on optogenetics, a technique that makes specific neurons sensitive to light so they can be precisely controlled.
Published in Advanced Materials Technologies, the research demonstrates how ICOPS could be used to map and control the intestinal nervous system without surgery. “If you look at how we do any study trying to map neural function in the gut, it is all extremely crude,” said Ramadi. “We just do not have good tools for it.”
Current approaches often require invasive surgery to implant optical fibres. ICOPS avoids this by using an LED-equipped capsule called ‘Light Pill” that patients swallow after scientists modify certain gut neurons to respond to light. “You can go in, transfect a certain subset of cells to be light sensitive, and then swallow this light pill whenever you want to activate those cells,” Ramadi explained.
How it works
The capsule works without a battery, receiving power wirelessly through magnetic induction from an external transmitter. “What makes this capsule unique is that it was entirely fabricated in-house using 3D printing, without the need for cleanroom facilities,” said Postdoctoral Associate at NYUAD and lead author Mohamed Elsherif. “It can operate wirelessly in freely moving animals, enabling studies that were not possible with traditional tethered or invasive approaches.”
Gut motility disorder
Beyond research, ICOPS could enable new treatments for gut motility disorders, metabolic diseases, and eating disorders by controlling neural activity in specific regions of the gut. Future versions could also provide electrical stimulation and targeted drug delivery.
In addition to Ramadi and Elsherif, co-authors include Rawan Badr El-Din, Zhansaya Makhambetova, Heba Naser, Rahul Singh, Keonghwan Oh, Revathi Sukesan, and Maylis Boitet (NYUAD), and Sohmyung Ha (NYUAD and NYU Tandon). The work was supported by the NYUAD Research Institute Award to the Research Center for Translational Medical Devices (CENTMED).
